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Alkalinization of urine hastens phenobarbital excretion, but dialysis and hemoperfusion are more practical and cause a lot less troublesome alterations in electrolyte equilibrium. In case the individual has chronically abused sedatives, withdrawal reactions may very well be manifest adhering to acute overdose.Barbiturates are metabolized mainly by

Check Carefully (1)phenobarbital will lower the level or result of fentanyl transmucosal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to your lessen in fentanyl plasma concentrations, not enough efficacy or, probably, development of a withdrawal